Supports· strongCOV-E016
The closest known relative, at roughly 96 percent whole-genome identity
- what the source states
- "Simplot analysis showed that 2019-nCoV was highly similar throughout the genome to RaTG13, with an overall genome sequence identity of 96.2%." On the spike: "The receptor-binding spike protein encoded by the S gene was highly divergent from other CoVs … with less than 75% nucleotide sequence identity to all previously described SARSr-CoVs, except for a 93.1% nucleotide identity to RaTG13."
- what we infer
- Roughly four percent whole-genome divergence represents decades of independent evolution, which is why no sampled relative can be the immediate progenitor. Note that the paper reports identity figures and concludes probable bat origin; the "too distant to be a progenitor" inference is drawn elsewhere, and is not attributed to these authors. Later peer-reviewed papers give this same figure as 96.1 percent.
- limitations
- Authored by the institute whose research is itself under scrutiny in this case — a conflict to record, not a reason to discount the sequencing.
- A statement about sampled diversity, not existing diversity.